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José Manuel García-Aznar, "Modeling the mechanics of cell locomotion"
Cell migration individually or collectively is crucial for all morphogenetic and regenerative processes, also contributing to the development of numerous diseases, including cancer. For individual cell migration, cell movement starts with protrusion of the cell membrane followed by the formation of new adhesions at the cell front that link the actin cytoskeleton to the extracellular matrix of the tissues, generation of traction forces that move the cell forwards and disassembly of adhesions at the cell rear. Therefore, cell locomotion is a multiscale process that results from the integrated effect of five main mechanical events that cells exert on the tissue matrix: cell polarization, protrusion, attachment to the matrix (adhesion), internal contraction, and detachment from the matrix at the cell rear.
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